Fibroid Support Combo
Supports uterine tissue health with a targeted approach to healthy estrogen metabolism, inflammation, oxidative stress and normal cellular growth. This comprehensive three-formula combo also helps ease occasional cramping and pelvic discomfort for greater comfort throughout the month.
Target the biology behind fibroid growth. Naturally.
Heavy periods. Pelvic pressure. Constant bathroom trips. Bone-deep fatigue.
If uterine fibroids have turned every month into something you brace for, you're not alone.
Up to 80% of women develop uterine fibroids before age 50, making them the most common benign tumor in women. But benign doesn't always mean symptom-free.
Fibroids can bring:
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Heavy menstrual bleeding
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Painful cramping
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Pelvic pressure
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Frequent urination
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Bloating
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Persistent fatigue
Conventional care still leans on managing symptoms with birth control pills, hormone therapy, and in severe cases, hysterectomy. Those options can have their place. But they aren't the only way to support your body.
That's why we developed Fibroid Support Combo.
Fibroids are multifactorial. Your fibroids solution should be too.
For years, the explanation for fibroids seemed simple: too much estrogen.
Today, research paints a much more complete picture. Fibroid growth is influenced by multiple interconnected biological systems, including estrogen metabolism, inflammation, oxidative stress, cellular signaling and Vitamin D status. When these systems fall out of balance, they create the conditions that allow fibroids to grow and symptoms like heavy bleeding, pelvic pain and pressure to develop.
Most natural fibroid products give you only one thing: DIM.
DIM matters — and we'll get to exactly why. But a single ingredient can only reach a single pathway. Fibroid Support Combo was built differently -- with clinically studied ingredients that work across multiple biological pathways to help restore healthier internal balance and support normal uterine tissue.
Three targeted formulas. One comprehensive approach.
Estrobiome Support — Build the foundation
DIM (diindolylmethane) helps your body metabolize estrogen into its healthier forms and is one of the most studied nutrients for estrogen balance. But our Estrobiome Support goes further, pairing DIM with calcium D-glucarate, broccoli sprout extract, curcumin, EGCG (green tea extract), and targeted botanicals to support healthy estrogen metabolism and detoxification pathways through a powerful added layer of antioxidant protection.
What the science says:
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"DIM supports healthier estrogen metabolism by shifting estrogen toward more favorable metabolites, an important strategy for estrogen-responsive conditions." — Nutrition Reviews Journal
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"Curcumin has demonstrated anti-inflammatory, anti-fibrotic and anti-proliferative effects in experimental models of uterine fibroids." — Journal of Clinical Medicine
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"Clinical evidence indicates a decrease in fibroid incidence, volume and growth rate with EGCG supplementation."— Journal of Clinical Medicine
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"Calcium D-glucarate enhances the excretion of metabolized estrogen and carcinogens." — Cancer Epidemiology, Biomarkers & Prevention
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"Sulforaphane [broccoli sprout extract] has demonstrated anti-inflammatory and antioxidant properties that may help counter biological pathways involved in fibroid development." — Nutrients Journal
Vitamin D3 -- Support healthy cellular communication
Vitamin D helps regulate normal cellular growth and healthy estrogen receptor activity — two processes central to healthy uterine tissue. The vitamin's connection to fibroid activity is striking: Vitamin D deficiency is consistently more common among women with fibroids, which makes optimal Vitamin D status a meaningful part of reproductive wellness.
Our Vitamin D3 (cholecalciferol)is the same form your body naturally produces in response to sunlight, and in supplement form, is highly absorbable. Each capsule delivers a flexible 1000 IU dose, making it easy to optimize your intake based on your individual needs.
What the science says:
"Four of five clinical studies show that Vitamin D significantly inhibited fibroid growth." — A Systematic Review of Vitamin D and Fibroids, Journal of Reproductive Sciences
Omega-3s -- Calm inflammation. Protect healthy tissue
Inflammation and oxidative stress help shape the very environment in which fibroids develop. Omega-3 fatty acids support a healthy inflammatory response while helping protect cells from free-radical damage — supporting healthier tissue over time. Our Omega-3s are molecularly distilled to concentrate these essential fatty acids and meaningful levels of EPA and DHA.
What the science says:
"Inflammation may play a significant role in the growth of uterine fibroids,.. with inflammatory markers elevated in fibroid tissue." — Journal of Reproductive Endocrinology
What to expect
Fibroids develop over months and years — so supporting the biology behind them takes time, too.
Some women notice improvements in menstrual comfort or overall well-being within a few cycles. The deeper benefits — healthier estrogen metabolism, balanced inflammatory activity, ongoing cellular support — build gradually with consistent daily use.
Fibroid Support Combo was designed to nourish those interconnected pathways with nutrients chosen for the research behind them — not to chase a single ingredient or silence a single symptom. By supporting your body's own processes, it helps create a healthier biological environment for long-term uterine wellness.
Who is Fibroid Support Combo for?
Fibroid Support Combo is for women who want a proactive, biology-first approach to uterine tissue health — whether you're managing symptoms now, thinking about the years ahead, or simply looking for more than a single-ingredient supplement can offer. It's designed to complement, not replace, the care you and your provider decide is right for you.
How to use
Take each supplement as directed on the package, at the same time each day if possible. Consult your healthcare provider if you have questions about use with medications or health conditions.
FAQs
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Uterine fibroids are non-cancerous growths that develop in the muscular wall of the uterus. They are incredibly common and can vary greatly in size, number and location. Some fibroids are as small as a seed, while others can grow large enough to change the shape of the uterus. Although fibroids are almost always benign, they can cause a wide range of symptoms depending on their size and location.
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Many women don't realize they have fibroids because they experience few or no symptoms. In fact, fibroids are often discovered during a routine pelvic exam or ultrasound. If you have symptoms such as unusually heavy menstrual bleeding, persistent pelvic pain or pressure, frequent urination or an enlarged abdomen, your healthcare provider may recommend imaging tests to determine whether fibroids are present.
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Fibroid symptoms vary from woman to woman and depend largely on the size, number and location of the fibroids. Common symptoms include:
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Heavy or prolonged menstrual bleeding
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Painful menstrual cramping
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Pelvic pain, pressure or fullness
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Frequent urination
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Bloating or abdominal fullness
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Lower back pain
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Pain during intercourse
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Persistent fatigue, often related to heavy menstrual bleeding
Some women experience only mild symptoms, while others find that fibroids significantly interfere with their daily activities and quality of life.
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Estrogen can influence fibroid growth, but it is only one part of the picture. Current research suggests that fibroids are influenced by several interconnected factors, including estrogen metabolism, inflammation, oxidative stress, cellular signaling and Vitamin D status.
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Depending on the size and location of the fibroids and the severity of symptoms, conventional options may include watchful waiting, medications to control heavy bleeding and pain, hormone-based treatments, uterine artery embolization, myomectomy or hysterectomy.
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Fibroid Support is a three-part nutritional supplement program designed to support the biological pathways involved in maintaining a healthy uterine environment. It combines Estrobiome Support, Vitamin D3 and Omega-3 to provide comprehensive support for healthy estrogen metabolism, inflammatory balance, cellular communication and uterine tissue health.
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DIM, or diindolylmethane, is a natural compound produced when the body digests cruciferous vegetables such as broccoli and cauliflower. It supports the healthy metabolism and clearance of estrogen, helping the body convert estrogen into healthier forms. Because fibroids are highly responsive to estrogen, supporting the way estrogen is processed is an important part of maintaining a healthier uterine environment.
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Vitamin D helps regulate normal cellular growth, healthy estrogen receptor activity and the cellular communication needed to maintain healthy uterine tissue. Research also shows that Vitamin D deficiency is more common among women with fibroids. Maintaining healthy Vitamin D levels may help promote a uterine environment that is less supportive of the conditions fibroids need to thrive.
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Inflammation and oxidative stress can help create an internal environment that supports fibroid development. Omega-3 fatty acids promote a healthy inflammatory response while helping protect uterine cells from free-radical damage. Over time, this support may contribute to healthier uterine tissue and greater menstrual and pelvic comfort.
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Many natural fibroid products rely primarily on DIM. While DIM is important for healthy estrogen metabolism, fibroids are influenced by multiple biological pathways. Fibroid Support takes a more comprehensive approach with three complementary formulas:
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Estrobiome Support pairs DIM with calcium D-glucarate, broccoli sprout extract and targeted botanicals to support healthy estrogen metabolism and clearance, balanced hormone signaling and antioxidant protection.
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Vitamin D3 supports normal cellular growth, healthy estrogen receptor activity and the cellular communication needed to maintain healthy uterine tissue. Healthy Vitamin D status is especially important because low Vitamin D levels are commonly associated with fibroids.
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Omega-3 helps balance inflammatory activity and protect uterine cells from oxidative stress, two factors that can contribute to an internal environment that supports fibroid development.
Together, these formulas help promote healthier uterine terrain that is less supportive of the conditions fibroids need to thrive.
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Fibroid Support Combo provides daily nutritional support for the interconnected biological pathways involved in fibroid wellness. By promoting healthy estrogen metabolism, balanced inflammatory activity, protection from oxidative stress and healthy cellular signaling, it helps create a healthier uterine environment over time. With consistent use, some women may also notice improvements in menstrual comfort, pelvic comfort and overall well-being.
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Fibroid Support Combo is not intended to shrink or eliminate fibroids. Instead, it supports the biological pathways involved in fibroid growth, helping promote healthier uterine terrain that is less supportive of the conditions fibroids need to thrive. It is designed to complement, not replace, medical evaluation or treatment recommended by your healthcare provider.
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Fibroids and the biological imbalances associated with them develop over months and years, so nutritional support takes time too. Some women may notice improvements in menstrual comfort or overall well-being within a few cycles. Deeper support for estrogen metabolism, inflammatory balance and cellular health builds gradually with consistent daily use.
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Fibroid Support Combo is designed to complement the care you and your healthcare provider determine is right for you. Because individual treatments, medications and health needs vary, talk with your provider before starting the combination, especially if you use hormone-based medication, take prescription drugs, are preparing for a procedure, are pregnant or breastfeeding or have an existing medical condition.
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DIM (Diindolylmethane) & Broccoli Sprout (Sulforaphane)
Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study: Effect of 3,3′-diindolylmethane supplements on urinary estrogen metabolites. Nutr Cancer. 2004;50(2):161-167. PMID: 15623462.
Thomson CA, Chow HHS, Wertheim BC, et al. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat. 2017;165(1):97-107. PMCID: PMC5571834.
Newman MS, et al. The impact of 3,3′-diindolylmethane on estrogen metabolism in postmenopausal women on transdermal estradiol therapy. Maturitas. 2025. PMID: 40298801.
Yagishita Y, et al. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens and oxidative stress. Nutr Cancer. 2019. PMCID: PMC6804255.
Fahey JW, et al. Bioavailability of sulforaphane following ingestion of glucoraphanin-rich broccoli sprout extracts with active myrosinase. Nutrients. 2019. PMCID: PMC31261930.
Curcumin (Meriva®)
Peng Y, Ao M, Dong B, Jiang Y, Yu L, Chen Z, Hu C, Xu R. Anti-inflammatory effects of curcumin in inflammatory diseases: Status, limitations and countermeasures. Drug Des Devel Ther. 2021;15:4503-4525. PMCID: PMC8572027.
Hewlings SJ, Kalman DS. Curcumin: A review of its effects on human health. Foods. 2017;6(10):92. PMCID: PMC5664031.
Olivera A, et al. Inhibition of the NF-κB signaling pathway by curcumin. J Biol Chem. 2011. PMCID: PMC3372981.
Green Tea (EGCG)
Fuhrman BJ, et al. Associations of green tea intake with urinary estrogen profiles in Japanese-American women. Nutr Cancer. 2013. PMCID: PMC3584908.
Fernandez JW, Rezai-Zadeh K, Obregon D, Tan J. EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP. FEBS Lett. 2010. PMCID: PMC2981607.
Mokra D, Joskova M, Mokry J. Therapeutic effects of green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and apoptosis. Int J Mol Sci. 2022. PMCID: PMC9820274.
Rosemary
Rahbardar MG, et al. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders, inflammation, and oxidative stress. Iran J Basic Med Sci. 2020. PMCID: PMC7491497.
Gonçalves C, et al. Systematic review of rosemary's anti-inflammatory and antioxidant effects. Phytother Res. 2022. PMID: 35163873.
Vitamin D3
Al-Hendy A, et al. Vitamin D3 inhibits proliferation of human uterine fibroid cells. Biol Reprod. 2014;90(5):115. PMCID: PMC4209245.
Baird DD, et al. Vitamin D and the risk of uterine fibroids. Epidemiology. 2013;24(3):447-453. PMID: 23493030.
Ali M, Al-Hendy A, Yang Q, et al. A systematic review of vitamin D and fibroids: Pathophysiology, prevention, and treatment. Obstet Gynecol Surv. 2022;77(12):713-724.
Fibroids & Nutritional Interventions
Ploumaki I, Sayed A, Al-Hendy A, Diamond MP. The potential of vitamin D and epigallocatechin gallate (EGCG) for prevention and treatment of uterine fibroids. Mol Nutr Food Res. 2025;69(22):e70231. PMID: 40887800.
Paffoni A, Somigliana E, Viganò P, et al. Nutrition and uterine fibroids: A systematic review of dietary factors and nutritional interventions. Nutrients. 2024;16(6):807.
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Reviews for Fibroid Support Combo
Includes reviews for Fibroid Support Combo, along with its individual components
Ingredients for Fibroid Support Combo