There is no cure for Endometriosis, but the science of its action is well-understood, and targeted supplements play an important role in finding symptom relief.
Pathways to Symptom Relief
Research shows that Endometriosis progresses, and its symptoms worsen, through four pathways:
-
Imbalanced estrogen metabolism
-
Chronic inflammation, especially prostaglandin-driven
-
Oxidative stress
-
Impaired immune function
These pathways work together to create cell proliferation, inflammation, and pain, often tracking the menstrual cycle.
How It works
The Endo Combo works on each of these pathways to help with symptom relief:
-
Inflammatory Support & Oxidative Balance: Curcumin, vitamin C, green tea, lycopene, and magnesium work together to calm inflammatory pathways and neutralize oxidative stress—key drivers of pelvic discomfort.
-
Hormone Modulation & Estrogen Balance: Phytoestrogens (red clover, kudzu, black cohosh), chasteberry, and wild yam help modulate estrogen receptor activity. Curcumin also suppresses estradiol production and attenuates endometrial cell proliferation.
-
Muscle Relaxation & Cramp Relief: There is good evidence that magnesium helps relieve menstrual cramps. Mechanistically, it works by reducing prostaglandin-driven pain, relaxing uterine smooth muscle, and calming nerve hypersensitivity
Use With Our Protocol for Best Results
The science is also clear that modest lifestyle changes – sleep, movement, diet, stress management – yield tremendous benefit. A Quick Start summary is included with every purchase. When combined with the Endo Combo, this will bring you the best results – maximum relief in the shortest possible time.
Dig Deeper Into The Elements
Designed to support healthy inflammatory response, hormonal balance, and oxidative resilience, the Endo Combo brings together three targeted formulas: Herbal Equilibrium, Super-C, and Magnesium Bisglycinate. Each delivers scientifically backed mechanisms to help ease discomfort, promote cellular integrity, and support hormonal harmony—key to natural comfort and resilience.



FAQs
-
No. Endometriosis is a complex condition with distinct diagnosis and treatment protocols. This combo is formulated to support healthy inflammatory response, hormone balance, and oxidative resilience — but it's not a treatment or cure.
-
Yes. The ingredients are designed to complement one another. However, if you are on medication or have medical conditions, please consult your healthcare provider.
-
Some users notice improved comfort and energy within weeks; others experience best results after consistent use over several months.
-
These ingredients are generally well tolerated. Some individuals may experience mild digestive changes or hormonal shifts. If any discomfort arises, consider adjusting usage or consulting a healthcare professional.
-
Because some herbal components and antioxidants can interact with medications (e.g., hormonal therapies, blood thinners), it’s important to consult your healthcare provider before beginning.
-
No. Due to the hormonal activity of certain ingredients, this combo is not recommended during pregnancy or breastfeeding.
-
Ashwagandha (Withania somnifera)
Majeed, M., et al. (2023).A standardized Ashwagandha root extract alleviates stress and anxiety by reducing cortisol and increasing serotonin in healthy adults. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/37832082/
Speers, A. B., et al.(2021). Effects of Withania somnifera extracts on stress and anxiety: Animal and human studies review. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/34254920/
Arumugam, V., et al.(2024). Effects of Ashwagandha formulations on stress and anxiety: Systematic review and meta-analysis. Journal of Affective Disorders. Retrieved from https://pubmed.ncbi.nlm.nih.gov/39348746/
Passion Flower (Passiflora incarnata)
Akhondzadeh, S., Naghavi,H.-R., & Vazirian, M. (2001). Passionflower extract versus oxazepam in generalized anxiety disorder: Randomized clinical trial. J Clin Pharm Ther. Retrieved from https://pubmed.ncbi.nlm.nih.gov/11679026/
Nojoumi, M., et al. (2016).Passionflower as an add-on in treatment of generalized anxiety disorder:Clinical trial. Journal/Source.Retrieved from https://pubmed.ncbi.nlm.nih.gov/27928252/
Harit, M. K., et al.(2024). Passion flower extract improves stress resistance and quality of life: Randomized, double-blind clinical trial. Journal/Source. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11026993/
ChasteTree Berry (Vitex agnus-castus)
Csupor, D., et al. (2019).Vitex agnus-castus in premenstrual syndrome: Meta-analysis of RCTs. Complementary Therapies in Medicine, 47,102190. Retrieved from https://pubmed.ncbi.nlm.nih.gov/31780016/
van Die, M. D., Bone, K.M., Tum, H., & Leach, M. J. (2013). Vitex extracts for female reproductivedisorders: Systematic review. PhytotherRes. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23136064/
Schellenberg, R. (2012). Dose-dependent efficacy of VAC extract (Ze 440) in relieving PMS symptoms. Phytomedicine. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23022391/
Meriva®(Curcumin Phytosome)
Pivari, F., et al. (2022).Curcumin supplementation (Meriva®) modulates inflammation, oxidative status,and gut microbiota in CKD patients. Nutrients,14(1), 231. Retrieved from https://pubmed.ncbi.nlm.nih.gov/35011106/
Antiga, E., et al. (2015). Oral Meriva® as adjuvant therapy in psoriasis: Randomized, placebo-controlled trial. BioMed Res Int. Retrieved fromhttps://pubmed.ncbi.nlm.nih.gov/25621183/
Drobnic, F., et al. (2014).Curcumin delivery system (Meriva®) reduces delayed-onset muscle soreness: RCT. J Int Soc Sports Nutr., 11, 31.Retrieved from https://pubmed.ncbi.nlm.nih.gov/24982601/
GreenTea Extract (Catechins)
Fuhrman, B. J., et al.(2013). Green tea intake associated with urinary estrogen profiles in women. Nutrition and Cancer. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23413779/
Wu, A. H., et al. (2005). Tea and circulating estrogen levels in postmenopausal women. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15661801/
Wan, Z., et al. (2023).Long-term green tea consumption reduces depression risk by reducing inflammation and increasing estradiol in postmenopausal women. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/37960167/
Lycopene
Mirahmadi, M., et al.(2023). Lycopene modulates oxidative stress and liver enzyme levels in metabolic syndrome patients: RCT. Cell J.,25(12), 847–853. Retrieved from https://pubmed.ncbi.nlm.nih.gov/38192255/
Chen, J., et al. (2013).Effect of lycopene supplementation on oxidative stress: Systematic review andmeta-analysis of RCTs. J Med Food,16(5), 361–374. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23631493/
Rao, L. G., et al. (2007).Lycopene decreases oxidative stress and bone resorption markers inpostmenopausal women: RCT. OsteoporosInt., 18(1), 109–115. Retrieved from https://pubmed.ncbi.nlm.nih.gov/16941193/
Magnesium Bisglycinate (Magnesium)
Supakatisant, C., & Thawatchaijaroen, P. (2012). Oral magnesium bisglycinate chelate improves frequency and intensity of pregnancy-induced leg cramps: A randomized trial. Journal Name. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860204/
Garrison, S. R., et al.(2020). Magnesium supplements and skeletal muscle cramps: A critical review. J Clin Med. Retrieved from https://pubmed.ncbi.nlm.nih.gov/32956536/
Reno, A. M., Green, M., Killen, L. G., O'Neal, E. K., Pritchett, K., & Hanson, Z. (2022). Effects of magnesium supplementation on muscle soreness and performance: A randomized, double-blind study. J Strength Cond Res,36(8), 2198–2203. Retrieved from https://pubmed.ncbi.nlm.nih.gov/33009349/
Fatima, G., et al. (2024).“Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases.” Cureus. Broad review covering Mg biology and clinical links; includes sections on how adequate magnesium supports mitochondrial function and helps limit oxidative stress–related damage. https://pmc.ncbi.nlm.nih.gov/articles/PMC11557730/
Cepeda, V., et al. (2025).“Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis.” Antioxidants (Basel). Synthesizes RCTs on magnesium and biomarkers (TAC, MDA,GSH, NO, CRP); reports a significant reduction in CRP but mixed/limited effects on oxidative-stress markers overall. https://pmc.ncbi.nlm.nih.gov/articles/PMC12189353/
Zheltova AA, Kharitonova MV, Iezhitsa IN, Spasov AA. Magnesium deficiency and oxidative stress: an update. Biomedicine (Taipei). 2016. (Summarizes human/animal data showing Mg deficiency elevates lipid/protein/DNA oxidation and weakens antioxidant defenses.) https://pmc.ncbi.nlm.nih.gov/articles/PMC5112180/
Liu M, Dudley SC Jr. Magnesium, oxidative stress, inflammation, and cardiovascular disease. Antioxidants (Basel). 2020. (Mechanistic review: low intracellular Mg drives mitochondrial ROS, downregulates MnSOD/catalase, and contributes to cardiometabolic pathology; includes clinical evidence context.) https://pmc.ncbi.nlm.nih.gov/articles/PMC7598282/
Cazzola R, Della Porta M, Piuri G, Maier JA. Magnesium: A defense line to mitigate inflammation and oxidative stress in adipose tissue. Antioxidants (Basel). 2024. (Narrative review on Mg’s role in limiting adipose-tissue oxidative stress and related metabolic dysfunction.) https://pmc.ncbi.nlm.nih.gov/articles/PMC11351329/
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
|
Reviews for Endo Combo
No reviews for this product yet
Ingredients for Endo Combo
