There is no cure for Endometriosis, but the science of its action is well-understood, and targeted supplements play an important role in finding symptom relief.
Pathways To Symptom Relief
Research shows that Endometriosis progresses, and its symptoms worsen, through four vectors:
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Imbalanced estrogen metabolism
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Chronic inflammation
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Oxidative stress
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Impaired immune function
These pathways work together to create cell proliferation, inflammation, and pain, often tracking the menstrual cycle.
"Supplementation with antioxidant vitamins significantly reduced dysmenorrhea and improved dyspareunia (painful intercourse), and pelvic pain, resulting in meaningful improvements in quality of life for women with endometriosis."
— Journal of Reproductive Biology & Endocrinology
FAQs
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Yes, but we recommend checking with your healthcare provider first, especially if you’re taking hormone therapy or prescription anti-inflammatories. All ingredients in Endo Combo are naturally derived and designed to complement most treatment plans.
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Most women notice benefits within one to two cycles, with continued improvement over time. Endo Combo is safe and effective for ongoing daily use.
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The formulas are most effective together, but you can personalize your routine depending on your needs. Many women continue with EstroBiome and Omega-3s daily, adding Herbal Equilibrium and Magnesium Bisglycinate during times of greater discomfort or stress.
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No. Due to the hormonal impact of certain ingredients, this combo is not recommended during pregnancy or breastfeeding.
How Endo Combo Works To Relieve All Four Vectors
Inflammatory Relief & Oxidative Balance
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Curcumin, vitamin C, green tea, lycopene, and magnesium work together to calm inflammatory pathways and neutralize oxidative stress—key drivers of pelvic discomfort.
Hormone Modulation & Estrogen Balance
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Phytoestrogens (red clover, kudzu, black cohosh), chasteberry, and wild yam help modulate estrogen receptor activity. Curcumin also suppresses estradiol production and attenuates endometrial cell proliferation.
Muscle Relaxation & Cramp Relief
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There is good evidence that magnesium helps relieve menstrual cramps. Mechanistically, it works by reducing prostaglandin-driven pain, relaxing uterine smooth muscle, and calming nerve hypersensitivity
How our Endo Combo helps
Hormonal symptoms:
Heavy periods, severe PMS, bloating, period pain
Phytoestrogens improve hormone signaling and support estrogen balance. Magnesium Bisglycinate relaxes uterine muscle and reduces prostaglandin-driven pain.
Chronic inflammation:
Pelvic pain, painful sex, low back pain
Meriva® curcumin, green tea extract, lycopene, and Vitamin C help calm inflammatory pathways and reduce pelvic discomfort.
Oxidative stress:
Worsening fatigue, brain fog, more frequent/severe flare-ups
Full-spectrum antioxidant support neutralizes oxidative stress and strengthens cellular resilience to diminish flare-ups.
The Tragedy Of Endometriosis
Endometriosis symptoms can affect every part of your well-being – from energy and mood to digestion and pelvic discomfort. While there’s no single approach that works for every woman, nourishing your body with targeted nutrients and herbal support specifically designed for Endometriosis can make areal difference in how you feel.
Three factors make endometriosis an especially tragic condition:
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It’s incurable. It appears to take many years to develop, but once in its full form, conventional medicine has no cure.
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It takes years to diagnose. On average it takes 5-10 from your first doctor’s visit to reach a firm diagnosis. For so many women, they discover the underlying problem only after their window of fertility has begun to vanish.
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Conventional treatment is largely ineffective. There is little evidence that conventional treatment slows the progression of the disease. Drugs for pain come with side effects. And surgery is not a cure, and may even hasten progression.
In this context, natural symptom relief, even if it’s partial, can be very meaningful.
4 Benefits Of WHN’s Endo Combo
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Promotes healthy estrogen metabolism for smoother, more predictable cycles
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Helps calm monthly inflammation and ease pelvic and muscle tension
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Supports mood stability, mental focus, and boosts energy
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Encourages better sleep and stress resilience
"The intake of vitamin C and vitamin E supplements effectively reduced dysmenorrhea severity and improved dyspareunia and severity of pelvic pain."
https://pmc.ncbi.nlm.nih.gov/articles/PMC8172324/
"After treatment with vitamins [C + E], chronic pain improved in 43% of patients in group A. In the same group, dysmenorrhea (pain associated with menstrual bleeding) and dyspareunia (pain with sex) decreased 37% and 24%, respectively."
https://www.fertstert.org/article/S0015-0282(03)01504-8/fulltext
"Treatment with Curcumin... can inhibit invasion, attachment, and angiogenesis of endometrial lesions. Thus, it may have potential benefits as a dietary and pharmacological agent for the prevention and treatment of endometriosis."
https://www.sciencedirect.com/science/article/pii/S0753332217346838
How It Works
You’ll notice more ease, steadier energy, and a greater sense of control over your cycle — all with fewer ups and downs. Here’s how it works:
What To Expect
Within the first few weeks, you may notice more predictable cycles, easier flow, and fewer flare-ups of pelvic tension. Over time, Endo Combo helps your body find its natural rhythm – less inflammation, steadier moods, deeper sleep, and renewed vitality that lasts month after month.
Directions For Use
● Herbal Equilibrium: 2 capsules daily with food
● Super C Plus: 2 capsules daily
● Magnesium Glycinate: 2 capsules daily, preferably in the evening
Feel Balanced. Feel Supported. Feel Like Yourself.
Endo Combo gives you the daily foundation your body needs to stay balanced, calm, and pain-free — naturally. It’s your complete nutrient and herbal system for pelvic comfort that lasts all month long.
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Ashwagandha (Withania somnifera)
Majeed, M., et al. (2023).A standardized Ashwagandha root extract alleviates stress and anxiety by reducing cortisol and increasing serotonin in healthy adults. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/37832082/
Speers, A. B., et al.(2021). Effects of Withania somnifera extracts on stress and anxiety: Animal and human studies review. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/34254920/
Arumugam, V., et al.(2024). Effects of Ashwagandha formulations on stress and anxiety: Systematic review and meta-analysis. Journal of Affective Disorders. Retrieved from https://pubmed.ncbi.nlm.nih.gov/39348746/
Passion Flower (Passiflora incarnata)
Akhondzadeh, S., Naghavi,H.-R., & Vazirian, M. (2001). Passionflower extract versus oxazepam in generalized anxiety disorder: Randomized clinical trial. J Clin Pharm Ther. Retrieved from https://pubmed.ncbi.nlm.nih.gov/11679026/
Nojoumi, M., et al. (2016).Passionflower as an add-on in treatment of generalized anxiety disorder:Clinical trial. Journal/Source.Retrieved from https://pubmed.ncbi.nlm.nih.gov/27928252/
Harit, M. K., et al.(2024). Passion flower extract improves stress resistance and quality of life: Randomized, double-blind clinical trial. Journal/Source. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11026993/
ChasteTree Berry (Vitex agnus-castus)
Csupor, D., et al. (2019).Vitex agnus-castus in premenstrual syndrome: Meta-analysis of RCTs. Complementary Therapies in Medicine, 47,102190. Retrieved from https://pubmed.ncbi.nlm.nih.gov/31780016/
van Die, M. D., Bone, K.M., Tum, H., & Leach, M. J. (2013). Vitex extracts for female reproductivedisorders: Systematic review. PhytotherRes. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23136064/
Schellenberg, R. (2012). Dose-dependent efficacy of VAC extract (Ze 440) in relieving PMS symptoms. Phytomedicine. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23022391/
Meriva®(Curcumin Phytosome)
Pivari, F., et al. (2022).Curcumin supplementation (Meriva®) modulates inflammation, oxidative status,and gut microbiota in CKD patients. Nutrients,14(1), 231. Retrieved from https://pubmed.ncbi.nlm.nih.gov/35011106/
Antiga, E., et al. (2015). Oral Meriva® as adjuvant therapy in psoriasis: Randomized, placebo-controlled trial. BioMed Res Int. Retrieved fromhttps://pubmed.ncbi.nlm.nih.gov/25621183/
Drobnic, F., et al. (2014).Curcumin delivery system (Meriva®) reduces delayed-onset muscle soreness: RCT. J Int Soc Sports Nutr., 11, 31.Retrieved from https://pubmed.ncbi.nlm.nih.gov/24982601/
GreenTea Extract (Catechins)
Fuhrman, B. J., et al.(2013). Green tea intake associated with urinary estrogen profiles in women. Nutrition and Cancer. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23413779/
Wu, A. H., et al. (2005). Tea and circulating estrogen levels in postmenopausal women. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15661801/
Wan, Z., et al. (2023).Long-term green tea consumption reduces depression risk by reducing inflammation and increasing estradiol in postmenopausal women. Journal/Source. Retrieved from https://pubmed.ncbi.nlm.nih.gov/37960167/
Lycopene
Mirahmadi, M., et al.(2023). Lycopene modulates oxidative stress and liver enzyme levels in metabolic syndrome patients: RCT. Cell J.,25(12), 847–853. Retrieved from https://pubmed.ncbi.nlm.nih.gov/38192255/
Chen, J., et al. (2013).Effect of lycopene supplementation on oxidative stress: Systematic review andmeta-analysis of RCTs. J Med Food,16(5), 361–374. Retrieved from https://pubmed.ncbi.nlm.nih.gov/23631493/
Rao, L. G., et al. (2007).Lycopene decreases oxidative stress and bone resorption markers inpostmenopausal women: RCT. OsteoporosInt., 18(1), 109–115. Retrieved from https://pubmed.ncbi.nlm.nih.gov/16941193/
Magnesium Bisglycinate (Magnesium)
Supakatisant, C., & Thawatchaijaroen, P. (2012). Oral magnesium bisglycinate chelate improves frequency and intensity of pregnancy-induced leg cramps: A randomized trial. Journal Name. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860204/
Garrison, S. R., et al.(2020). Magnesium supplements and skeletal muscle cramps: A critical review. J Clin Med. Retrieved from https://pubmed.ncbi.nlm.nih.gov/32956536/
Reno, A. M., Green, M., Killen, L. G., O'Neal, E. K., Pritchett, K., & Hanson, Z. (2022). Effects of magnesium supplementation on muscle soreness and performance: A randomized, double-blind study. J Strength Cond Res,36(8), 2198–2203. Retrieved from https://pubmed.ncbi.nlm.nih.gov/33009349/
Fatima, G., et al. (2024).“Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases.” Cureus. Broad review covering Mg biology and clinical links; includes sections on how adequate magnesium supports mitochondrial function and helps limit oxidative stress–related damage. https://pmc.ncbi.nlm.nih.gov/articles/PMC11557730/
Cepeda, V., et al. (2025).“Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis.” Antioxidants (Basel). Synthesizes RCTs on magnesium and biomarkers (TAC, MDA,GSH, NO, CRP); reports a significant reduction in CRP but mixed/limited effects on oxidative-stress markers overall. https://pmc.ncbi.nlm.nih.gov/articles/PMC12189353/
Zheltova AA, Kharitonova MV, Iezhitsa IN, Spasov AA. Magnesium deficiency and oxidative stress: an update. Biomedicine (Taipei). 2016. (Summarizes human/animal data showing Mg deficiency elevates lipid/protein/DNA oxidation and weakens antioxidant defenses.) https://pmc.ncbi.nlm.nih.gov/articles/PMC5112180/
Liu M, Dudley SC Jr. Magnesium, oxidative stress, inflammation, and cardiovascular disease. Antioxidants (Basel). 2020. (Mechanistic review: low intracellular Mg drives mitochondrial ROS, downregulates MnSOD/catalase, and contributes to cardiometabolic pathology; includes clinical evidence context.) https://pmc.ncbi.nlm.nih.gov/articles/PMC7598282/
Cazzola R, Della Porta M, Piuri G, Maier JA. Magnesium: A defense line to mitigate inflammation and oxidative stress in adipose tissue. Antioxidants (Basel). 2024. (Narrative review on Mg’s role in limiting adipose-tissue oxidative stress and related metabolic dysfunction.) https://pmc.ncbi.nlm.nih.gov/articles/PMC11351329/
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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